Sunday, August 21, 2016

John E. Buster: The doctor that helped create embryo transfer

Dr. John E. Buster
John Edmond Buster (born July 18, 1941) who worked at the University of California at Los Angeles School of Medicine, directed the research team that performed history's first embryo transfer from one woman to another resulting in a live birth. It was performed at the Harbor-UCLA Medical Center, reported in July 1983, and led to the announcement of the first human birth February 3, 1984. In the procedure, an embryo that was just beginning to develop was transferred from the woman in whom it had been conceived by artificial insemination to another woman who gave birth to the infant 38 weeks later. The sperm used in the artificial insemination came from the husband of the woman who bore the baby.

This scientific breakthrough established standards and became an agent of change for women suffering from the afflictions of infertility and for women who did not want to pass on genetic disorders to their children. Donor embryo transfer has given women a mechanism to become pregnant and give birth to a child that will contain their husband’s genetic makeup. Although donor embryo transfer as practiced today has evolved from the original non-surgical method, it now accounts for approximately 10% of in vitro fertilization recorded births.

Prior to this, thousands of women who were infertile, had adoption as the only path to parenthood. This set the stage to allow open and candid discussion of embryo donation and transfer. This breakthrough has given way to the donation of human embryos as a common practice similar to other donations such as blood and major organ donations. At the time of this announcement the event was captured by major news carriers and fueled healthy debate and discussion on this practice which impacted the future of reproductive medicine by creating a platform for further advancements in woman's health.

Buster and other members of the UCLA research team were featured on The Today Show, NBC News, Good Morning America, Oprah Winfrey, Phil Donahue and showcased in leading print publications such as the New York Times, New York Times Magazine, Los Angeles Times, Wall Street Journal, People Magazine, and Time Magazine.

This work established the technical foundation and legal-ethical framework surrounding the clinical use of human oocyte and embryo donation, a mainstream clinical practice, which has evolved over the past 25 years. Building upon Buster's research, and since the initial birth announcement in 1984, well over 200,000 live births resulting from donor embryo transfer have been, and continue to be, recorded by the Centers for Disease Control(CDC) in the United States to infertile women, who otherwise would not have had children by any other existing method.

For this work and in addition to a number of groundbreaking medical advancements in women's health, notably in the field of reproductive medicine Buster received the Legends Award in May 2012. "Legends" are selected based upon their internationally recognized contributions to medicine through research and innovative clinical practice. It was awarded by The Los Angeles Biomedical Research Institute (LA BioMed or LABioMed) located at Harbor-UCLA Medical Center.


INFERTILE WOMAN HAS BABY THROUGH EMBRYO TRANSFER
By SANDRA BLAKESLEE
Published: February 4, 1984

embryo transfer
LONG BEACH, Calif., Feb. 3— The birth of the first baby conceived in one woman's womb and carried to birth in another's without the use of ''test tube'' fertilization was announced here today by a team of California physicians.

The baby, a boy born about two weeks ago, ''is just beautiful,'' said the team leader, Dr. John E. Buster of the University of California at Los Angeles School of Medicine. He described the embryo transfer technique, long used in cattle but just now applied to humans, at a news conference at Long Beach Memorial Hospital. The technique does not require surgery, anesthetic or test tube fertilization of the egg, Dr. Buster said. A report of the birth appears in today's issue of The Journal of the American Medical Association.

In the procedure, an embryo that was just beginning to develop was transferred from one woman in whom it had been conceived by artificial insemination to another woman who gave birth to the infant 38 weeks later. The sperm used in the artificial insemination came from the husband of the woman who bore the baby.

Dr. Buster said the technique was different from ''test tube'' fertilization, which involves surgical removal of an unfertilized egg from a woman, fertilization of the egg in a laboratory dish, and implantation of the fertilized egg into the womb. Technique Is Described

Australian researchers last month reported the first successful birth in which an egg donated by one woman was fertilized and then implanted in an infertile woman. It was similar to the procedure announced today in that it used a donor's egg that had already reached the embryo stage and then was implanted in another woman. But the Australian case still required fertilization of the egg in a glass dish rather than in the donor's body.

Along with a half-dozen colleagues, Dr. Buster described the technique and his plans to establish the first ovum transfer clinic at Memorial Hospital this spring.

The hormonal cycles of the egg donor and recipient must be well matched, the physicians said. Five days after a donor is artificially inseminated, her uterus is flushed out and if a healthy embryo is present it is inserted immediately into the recipient's uterus. The embryo may consist of only 8 to l0 cells and would not be visible to the naked eye.

Donors and recipients are also matched by blood type, Rh factor, and hair and eye color. Beneficiaries of Procedure

transfer technique
The embryo transfer technique should prove desirable to women who have defective ovaries and thus produce no functional eggs of their own, who are tired of surgery attempts that have not yet worked or who may carry genetic disorders, Dr. Buster said. As long as the infertile couple is willing to accept a donated egg, the technique can be carried out in a doctor's office. Fertility and Genetics Research Inc., a Chicago-based company that helped develop the technique, announced plans to establish a national computer base to handle a stock of fertilized eggs. It has also applied for patents on the instruments used in transferring human embryos.

The company's right to such patents and to set up clinics across the country has been challenged by Jeremy Rifkin, president of the Foundation for Economic Trends in Washington, because the technique ''reduces the process of human reproduction to a commercialized product to be bought and sold in the marketplace.'' Mr. Rifkin said he planned a suit in patent court.

But Dr. Buster said the recipient mother, a woman in her 30's who had an eight-year history of infertility, is not upset over such issues. ''She is very happy and has a beautiful baby,'' he said.

The research team has attempted 46 transfers and had two successes. The second woman pregnant by the technique will be ready to give birth soon, he said, adding, ''We are very proud.''


Edmond Beatty Buster Jr (b.1918, Parker Co, TX) FATHER

Edmond "Bate" Beatty Buster Sr (b. 1891, Parker Co, TX,) GRANDFATHER

Green N. Buster Buster (b. 1858, Lawrence Co, AR) GREAT-GRANDFATHER

John Francis Buster (b. 1831, VA) 2ND GREAT-GRANDFATHER

Francis Beatty Buster (b. 1818, Scott, VA) 3RD GREAT-GRANDFATHER

John Buster Sr. (b.1755  Orange, NC ) 4TH GREAT-GRANDFATHER

William Buster Jr. (b.1729  Albemarle, VA ) 5TH GREAT-GRANDFATHER

William Buster Sr. (b.1694, UK ) 6TH GREAT-GRANDFATHER


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